Neurodegenerative syndromes present as proteinopathies – does ribosomal infidelity contribute to the protein toxicity that is the driving force for neuronal cell loss? Intracellular and extracellular protein aggregates overwhelm the clearance capacity of cells and tissues. Proteins aggregate when hydrophobic residues are exposed. Hydrophobic residues become exposed when proteins are misfolded. Protein misfolding can originate from translational errors at the ribosome. Indeed, the most error‐prone process in gene expression is translation at the ribosome. Recent evidence indicates that manipulating the ribosomal (...) accuracy impacts on the lifespan of model organisms and a reduced translational accuracy is accompanied by neurodegeneration. The first hit in aging‐associated neurodegenerative disease may be the well‐documented decline of cellular buffering capacity by aging. A second hit that impacts on the quality of protein synthesis could be the driving force for the observed loss of proteostasis in neurodegeneration. This hypothesis provides an explanation for the late onset of most neurodegenerative diseases. (shrink)

Translation from German to English by Daniel Fidel Ferrer -/- What Does it Mean to Orient Oneself in Thinking? -/- German title: "Was heißt: sich im Denken orientieren?" -/- Published: October 1786, Königsberg in Prussia, Germany. By Immanuel Kant (Born in 1724 and died in 1804) -/- Translation into English by Daniel Fidel Ferrer (March, 17, 2014). The day of Holi in India in 2014. -/- From 1774 to about 1800, there were three intense philosophical and theological controversies (...) underway in Germany, namely: Fragments Controversy, the Pantheism Controversy, and the Atheism Controversy. Kant’s essay translated here is Kant’s respond to the Pantheism Controversy. During this period (1770-1800), there was the Sturm und Drang (Storm and Urge (stress)) movement with thinkers like Johann Hamann, Johann Herder, Friedrich Schiller, and Johann Goethe; who were against the cultural movement of the Enlightenment (Aufklärung). Kant was on the side of Enlightenment (see his Answer the Question: What is Enlightenment? 1784). -/- What Does it Mean to Orient Oneself in Thinking? / By Immanuel Kant (1724-1804). [Was heißt: sich im Denken orientieren? English]. (shrink)

What is attention? Attention is often seen as a subject matter for the hard sciences of cognitive and brain processes, and is understood in terms of sub-personal mechanisms and processes. Correspondingly, there still is a stark contrast between the central role attention plays for the empirical investigation of the mind in psychology and the neurosciences, and its relative neglect in philosophy. Yet, over the past years, several philosophers have challenged the standard conception. A number of interesting philosophical questions concerning the (...) nature of attention arise. This article provides an introduction to contemporary debates concerning these questions. In particular, it discusses the question of how the pre-theoretic conception of attention might be reconciled with a scientific conception, arguments that provide support for an anti-reductivist theory of attention, and sketches several recent anti-reductivist theories and their inter-relations. (shrink)

Nietzsche’s Ecce homo, Notebooks and Letters: 1888-1889 / Translation by Daniel Fidel Ferrer. ©2023 Daniel Fidel Ferrer. All rights reserved. -/- Ecce homo: How One Becomes What One Is (Ecce homo: Wie man wird, was man ist). -/- Who should read Nietzsche? You can disagree with everything Nietzsche wrote and re-read Nietzsche to sharpen your attack. Philosophy. Not for use without adult supervision (required). Philosophy is a designated area for adults only. Read at your own risk. You have (...) the pleasure of reading and of course disagree with all philosophy. Warning philosophical ideas are present. Reading Nietzsche does not mean you will gain anything, in fact, you might lose your previous ideas. -/- Nietzsche does not call this book an autobiography (he has written many short autobiographical sketches before); but rather, uses the expression “I tell myself my life”. -/- Nietzsche was the past philosopher who wrote about our future, “The time is coming when the struggle for the domination of the earth will be waged - it will be waged in the name of basic philosophical doctrines.” KGWB/NF-1881, 11[273]. The world has seen plenty of wars and death, since 1881. The process of the domination of the earth and world is still on-going. -/- What is Nietzsche’s overall project with Ecce homo? -/- Main Leitmotifs in Ecce homo. -/- Christianity as the denial of the will to life, revaluation of all values (Umwerthung aller Werthe), Amor fati, Dionysus as a god and his philosophy (future project for Nietzsche), overthrowing idols, two worlds (“true world" finally became a fable) against Plato eternal world and forms, eternal recurrence or the eternal return of the same (Nietzsche heaviest thought, also his most abysmal thought “abgründlichsten Gedanken”), opposite and counterpart to type of person decadent (décadent), “I count the overcoming of pity among the noble virtues”, against the concept of God (Christian), overman or superman (Übermensch), Will to Power (Wille zur Macht), great politics, immoralist, morality of the Christian church, and Declaration of war (“Kriegserklärung”). -/- Table of Contents -/- Motto [page 3]. Epigraph [pages 4-6]. -/- Preface to the Translation of Ecce homo [pages 7-16] -/- Major Leitmotifs in Nietzsche [pages 17-24]. -/- Translations from Nietzsche’s German to English include. -/- 1). Ecce homo: How One Becomes What One Is (Ecce homo: Wie man wird, was man ist. [pages 25-113]. -/- 2). This poem was included in the first publications of Ecce homo (1908). Glory and Eternity (Ruhm und Ewigkeit). [pages 114-124]. -/- 3). These are all of Nietzsche’s last notebooks (complete) they are numbered 21, 22, 23, and 24. There are a total of 82 notes. Final notes by Nietzsche from the Nachlass (Nachlaß). Sometime in German called the Notizheft. Nietzsche’s notebooks that include some drafts for Ecce homo and other topics he was thinking during his last writings. Dating from October 1888 until early Janurary 1889. [pages 125-191]. -/- 4). Nietzsche’s Letters Regarding Ecce homo. Nietzsche’s letters starting at the end of October 1888 discussing Ecce homo. These are not always the complete letters but include all of the passages of Nietzsche discussing Ecce homo. Complete translation of the last letter Nietzsche wrote. Dated until BVN-1889. #1256. Letter to Jacob Burckhardt in Basel. Turin, about 6 January 1889. [pages 192-223]. -/- Bibliographies [pages 224-254]. -/- Nietzsche’s Philosophy Final Thoughts [pages 255-259]. -/- Enjoy reading Nietzsche's last book. (shrink)

Belief revision theory and philosophy of science both aspire to shed light on the dynamics of knowledge – on how our view of the world changes in the light of new evidence. Yet these two areas of research have long seemed strangely detached from each other, as witnessed by the small number of cross-references and researchers working in both domains. One may speculate as to what has brought about this surprising, and perhaps unfortunate, state of affairs. One factor may be (...) that while belief revision theory has traditionally been pursued in a bottom- up manner, focusing on the endeavors of single inquirers, philosophers of science, inspired by logical empiricism, have tended to be more interested in science as a multi-agent or agent-independent phenomenon. (shrink)

Porsdam Mann and colleagues provide an overview of opportunities and risks associated with the use of personalized large language models (LLMs) for text production in bio)ethics (Porsdam Mann et al...

The Introduction to this volume identifies and briefly summarizes certain issues which have been of central concern to philosophers in the transcendental tradition, including: the question of its relation to metaphysics; the relation of transcendentalism to transcendental idealism; the Kantian concept of a condition of possibility; the concepts of transcendental logic and of transcendental proof or argumentation; the concept of the transcendental turn and the issue of its justification; and the standpoint of transcendental reflection.

We present a new notion of game equivalence that captures basic powers of interacting players. We provide a representation theorem, a complete logic, and a new game algebra for basic powers. In doing so, we establish connections with imperfect information games and epistemic logic. We also identify some new open problems concerning logic and games.

In vertebrate development, the HOX genes act to specify cell identity along much of the anterior‐posterior axis of the embryonic central nervous system. In all vertebrates examined to date, the vitamin A metabolite retinoic acid is implicated in the patterning of the anterior posterior axis and the induction of HOX gene expression. Two recent papers have extended the study of retinoic acid induction of HOX genes to the closest relatives of the vertebrates, amphioxus and tunicates(1,2). In both these species, exogenous (...) retinoic acid is able to induce ectopic expression of HOX 1 genes in the anterior central nervous system. This suggests that retinoic acid control of anterior‐posterior axis formation and HOX induction is not specific to vertebrates. However, in the more distantly related echinoderms and arthropods, retinoic acid does not seem to act in the same way. Thus the role of retinoic acid in anterior‐posterior axis specification may be a chordate innovation, perhaps linked to the evolution of another chordate character, the dorsal neural tube. (shrink)

Should artificial agents (such as robots) be granted moral status? This seems like an important question to resolve, given that we will encounter a growing number of increasingly sophisticated artificial agents in the not too distant future. However, many will think that before we can even start to tackle questions about the moral status of artificial agents, we first need to solve tricky issues in the philosophy of mind. After all, most orthodox views about moral status imply that only entities (...) with a mental life are eligible for moral status. But, whether an unfamiliar entity like an artificial agent has a mental life raises controversial questions in the philosophy of mind. Given this, one might hope that we can resolve questions about the moral status of robots via “minimalist” views that give sufficient conditions for granting moral status to an entity that we can know to be satisfied without knowing whether the entity in question has a mind. This paper argues that we should be pessimistic about the prospects of minimalist views avoiding controversial questions in the philosophy of mind, by arguing that minimalist sufficient conditions are only plausible if combined with assumptions in the philosophy of mind. (shrink)

Este texto revisa las principales aportaciones de Walter Lippmann contenidas en su obra Libertad y prensa, de reciente aparición en lengua castellana. Publicado originalmente en 1920, el libro de Lippmann nos permite conocer sus agudas reflexiones acerca de las relaciones entre medios de comunicación, opinión pública y clase política. El estudio de esas relaciones ocupa una parte fundamental de la obra ensayística de Lippmann, cuya vigencia y vitalidad permanecen hoy inalteradas. Lippmann no fue sólo el columnista político más influyente del (...) pasado siglo, sino un penetrante analista que se interroga sobre la objetividad informativa, la deficiente formación de los profesionales de la prensa y su discutible fibra moral. Sus observaciones trascienden el restringido mundo de los medios de comunicación para preguntarse si su funcionamiento deficiente no pone en cuestión la supervivencia misma de la democracia. (shrink)

Taking into account a survey made by Madrid Press Association among journa-lists and users of mass media, this article discusses the positions expressed by Carlos Ruíz (2008) and Hugo Aznar (2009) about the role that Ethics and Law play as a means to supervise the behaviour of mass media nowadays. Firstly, we will try to argue about the necessity of complementing the concept of journalism of classical liberalism with the contributions made by the so called social responsibility theory. Secondly, we (...) will show some of the limits of Law as a means of control of journalism practice and will defend the values and contributions of ethical reflection. Finally, we will point out the conditions that journalistic self- regulation must satisfy to act as a credible tool for regulation. (shrink)

Cataloguing: -/- Twilight of the Idols or How to Philosophize with a Hammer / By Friedrich Nietzsche (1844-1900). [Götzen-Dämmerung. English]. Translation of text, afterward, notes, letters, and appendixes by ©Daniel Fidel Ferrer, 2013. 1. Philosophy 2) Metaphysics 3) Philosophy, Germa 4) Philosophy, German -- 19th century 5) Philosophy, German – Greek influences I. Nietzsche, Friedrich Wilhelm, 1844-1900 II. Ferrer, Daniel Fidel, 1952- .

Las ideas expuestas por José Eusebio Caro en su obra inconclusa intitulada Mecánica social o Teoría del movimiento humano, considerado en su naturaleza, en sus efectos y en sus causas, en 1836, recoge aspectos característicos del pensamiento de las primeras décadas del Siglo XIX, con raíces algunas de ellas en ápocas anteriores. La riqueza intelectual de la obra en mención indujo la investigación analítica, de la cual da cuenta este documento, según la siguiente pregunta de investigación: ¿Cuáles son los rasgos (...) epistemológicos predominantes en las tesis filosóficas y sociológicas de José Eusebio Caro, en su obra póstuma inconclusa intitulada Mecánica social o teoría del movimiento humano, considerado en su naturaleza, en sus efectos y en sus causas? El estudio en torno a esta obra se concentra en precisar aspectos epistemológicos de una propuesta que comparte honores con el positivismo y con el surgimiento de la teoría social cuyas tesis dan paso al surgimiento de la sociología. Esto, en un particular siglo caracterizado por la búsqueda de la originalidad ideológica y política del continente americano, que esperaba resurgir lejos de la dominación española y cerca de los teóricos franceses y de los desarrollos ideológicos de Inglaterra. (shrink)

I show that the central notion of Constructive Empiricism, empirical adequacy, can be expressed syntactically and specifically in the Received View of the logical empiricists. The formalization shows that the Received View is superior to Constructive Empiricism in the treatment of theories involving constants or functions from observable to unobservable objects. It also suggests a formalization of ‘full empirical informativeness’ in Constructive Empiricism.

I provide an explicit formulation of empirical adequacy, the central concept of constructive empiricism, and point out a number of problems. Based on one of the inspirations for empirical adequacy, I generalize the notion of a theory to avoid implausible presumptions about the relation of theoretical concepts and observations, and generalize empirical adequacy with the help of approximation sets to allow for lack of knowledge, approximations, and successive gain of knowledge and precision. As a test case, I provide an application (...) of these generalizations to a simple interference phenomenon. (shrink)

Higher-Order Thought (HOT) theories of consciousness maintain that the kind of awareness necessary for phenomenal consciousness depends on the cognitive accessibility that underlies reporting. -/- There is empirical evidence strongly suggesting that the cognitive accessibility that underlies the ability to report visual experiences depends on the activity of the dorsolateral prefrontal cortex (dlPFC). This area, however, is highly deactivated during the conscious experiences we have during sleep: dreams. HOT theories are jeopardized, as I will argue. I will briefly present HOT (...) theories in the first section. Section 2 offers empirical evidence to the effect that the cognitive accessibility that underlies the ability to report depends on the dorsolateral prefrontal cortex: dlPFC is the neural correlate of HOTs. Section 3 shows the evidence we have of the deactivation of this brain area during dreams and, in section 4, I present my argument. Finally, I consider and rejoin two possible replies that my opponent can offer: the possibility of an alternative neural correlate of HOTs during dreams and the denial that we have phenomenally conscious experiences during sleep. (shrink)

Abstract Artificial language philosophy (also called ‘ideal language philosophy’) is the position that philosophical problems are best solved or dissolved through a reform of language. Its underlying methodology—the development of languages for specific purposes—leads to a conventionalist view of language in general and of concepts in particular. I argue that many philosophical practices can be reinterpreted as applications of artificial language philosophy. In addition, many factually occurring interrelations between the sciences and philosophy of science are justified and clarified by the (...) assumption of an artificial language methodology. (shrink)

Schools in Germany are frequently named after people. Thus, these persons are remembered in the public sphere. This article answers the question to what extent the school names in the federal state of Thuringia correspond with the history of scientific pedagogy. For this purpose, in a first step, the controversial discussion about key figures in pedagogy and history of education is presented. In a second step the entirety of all school names in Thuringia is considered and individual results are discussed. (...) As a rule, it is not pedagogues who lend their names to schools but writers, artists and political figures. Only one fifth of all schools named after a person are named after educators. It is found that the key figures in pedagogy are rarely available as namesakes, whereas in practice successful school founders are preferred as name-givers. Accordingly, the history of pedagogy is represented in a filtered way in school names. Based on these results, further research perspectives for research on school names are formulated. (shrink)

Resumen. El propósito de este artículo científico es presentar algunas reflexiones acerca de lasnecesidades que tienen todas las organizaciones de asumir los riesgos laborales como una filosofíaorganizacional y el desafío de la gerencia en entornos cada vez más cambiantes, y sobre todo mejorarlas condiciones laborales y de seguridad de su talento humano. Se conceptualiza los riesgos ygerencia de riesgos, desde diferentes posturas considerando aportes de recientes investigadores queenfatizan en la necesidad de elaborar programas y estructura de riesgos en cualquier tipo (...) deorganización. Asimismo se presenta cual es el escenario mundial más importante para el debatesobre riesgos, enfatizándose en el cumplimiento de la Declaración de Seúl sobre seguridad y salud enel trabajo; y finalmente, a manera de conclusión se presentan los principales desafíos para lagerencia.Palabras claves: Riesgos, riegos laborales, gerencia de riesgos.. The purpose of this scientific paper is to present some reflections on the needs of allorganizations have to take risks at work as an organizational philosophy and the challenge ofmanagement in ever-changing environments, and especially to improve working conditions andsafety of human talent. Is conceptualized the risks and risk management, considering contributionsfrom different positions of recent researchers emphasize the need to develop programs and riskstructure in any organization which is the present world's largest stage for the debate on riskemphasis on fulfillment of the Seoul Declaration on Safety and health at work, and finally, inconclusion we present the main challenges for management.Keywords. Risks, hazards occupational, risk management. (shrink)

Resumen. El propósito de este ensayo, fue desarrollar un modelo teórico a partir del liderazgo deservicio en las organizaciones, considerando como fundamento teórico servir para ser líder; lapropuesta se titula “Modelo Bombero para Equipos de Alto Desempeño, emulando al Modelo PERFORM de Blanchard. Este aporte teórico sirve para ser aplicado a cualquier organizaciónpública o privada, bien de servicios o productos.Palabras claves. Servicio, líder, modelo bombero, equipos de alto desempeño.. The purpose of this study was to develop a theoretical model from (...) service leadership inorganizations considering serve as a theoretical foundation for leadership, the proposal is entitled "Fireman Model for High Performance Teams, emulating the model of Blanchard PERFORM. Thist heoretical contribution is made to be applied to any public or private organization, either services orproducts.Keywords. Service, leader, firefighter model, high performance teams. (shrink)

Este trabajo pretende rastrear la concepción de la historia en la obra ensayística de Rafael Sánchez Ferlosio. La hoja de ruta que se sigue para ello consiste en establecer los vínculos que desde la Ilustración acaban derivando en la historia universal de Hegel. La crítica ferlosiana se vertebra mediante la filosofía de la historia primero de Benjamin y luego de Adorno, para concluir en una visión menos idealista de la narración histórica que, ya en el siglo XX se reconoce como (...) narración. El acerado escepticismo de Ferlosio le llevará a rechazar toda mistificación del acontecer histórico, especialmente la que produce la propia razón. (shrink)

We are all familiar with judgements about the persistence of people. Furthermore, we tend to structure certain attitudes and practices around such judgements because we think that personal identity matters for the relevant practical concerns. Response‐dependence views try to accommodate that personal identity matters by letting relevant attitudes and practices determine the personal identity relation for a particular person. This paper argues that genuine response‐dependence views are not well positioned to accommodate the connection between personal identity and what matters. Rather, (...) if we accept such a connection, this supports normative‐facts‐first views, according to which relevant normative facts determine personal identity. (shrink)

We characterize the expressive power of the modal mu-calculus on monotone neighborhood structures, in the style of the Janin-Walukiewicz theorem for the standard modal mu-calculus. For this purpose we consider a monadic second-order logic for monotone neighborhood structures. Our main result shows that the monotone modal mu-calculus corresponds exactly to the fragment of this second-order language that is invariant for neighborhood bisimulations.

Adrian Moore argues that Kant’s transcendental idealism is incoherent, and that its incoherence gives us an invaluable insight into the fundamental nature of metaphysics, motivating the reconception of metaphysical inquiry with which Moore concludes his story of the development of modern philosophy. My discussion has three parts. First, I focus on the treatment of Kant’s transcendental idealism in Moore’s earlier book, Points of View, and highlight ways in which Moore is, I argue, open to challenge. Second, I suggest that the (...) historical record does not bear out Moore’s criticism of Kant’s transcendental idealism. Third, I compare Moore’s response to the alleged incoherence of transcendental idealism with that of the German Romantics. (shrink)

One argument that has been suggested for conventionalism about personal identity is that it captures that certain disagreements about personal identity seem irresolvable, without being committed to the view that these disagreements are merely verbal. In this paper, I will take the considerations about disagreement used to motivate conventionalism seriously. However, I will use them to motivate a very different, novel, and as yet unexplored view about personal identity. This is the view that personal identity is a non-representational concept, the (...) nature of which isn’t to be accounted for in terms of what entity it represents, but its non-representational role. I highlight that we find structurally very similar concerns about disagreement in another philosophical debate, namely in meta-ethics. But, in meta-ethics, such sorts of considerations are, traditionally, thought to support one distinctive view: meta-ethical expressivism, a non-representational view about normative thought and discourse. This suggests that we should take a similar view seriously for personal identity. I also develop what such an unfamiliar view might look like, using expressivism as a template. On this view, judgements about personal identity are plans that regulate who to hold accountable. (shrink)

The sheer multitude of criteria of empirical significance has been taken as evidence that the pre-analytic notion being explicated is too vague to be useful. I show instead that a significant number of these criteria—by Ayer, Popper, Przełęcki, Suppes, and David Lewis, among others—not only form a coherent whole, but also connect directly to the theory of definition, the notion of empirical content as explicated by Ramsey sentences, and the theory of measurement; two criteria by Carnap and Sober are trivial, (...) but can be saved and connected to the other criteria by slight modifications. A corollary is that the ordinary language defense of Lewis, the conceptual arguments by Ayer and Popper, the theoretical considerations by Przełęcki, and the practical considerations by Suppes all apply to the same criterion or closely related criteria. Furthermore, the equivalence of some criteria allows for their individual justifications to be taken cumulatively and, together with the entailment relations between nonequivalent criteria, suggest criteria for general auxiliary assumptions, comparative criteria, and more liberal conceptions of observation. (shrink)

En este trabajo nos proponemos, en primer lugar, reconstruir brevemente el análisis de Michel Foucault acerca de la episteme moderna, para luego analizar algunos rastros que identificamos en ciertos textos del pensador francés sobre la episteme contemporánea. A los fines de lograr este cometido, en tercer lugar, analizamos algunos textos de algunos pensadores del posestructuralismo francés y de la Mass Communication Research. Finalmente, concluimos que el acontecimiento que da lugar a la reconfiguración del saber occidental y a la conformación de (...) la episteme contemporánea está relacionado con las cuestiones del sentido y de la información, que contribuyen a delinear los contornos de las características del hombre y el lenguaje en la nueva episteme. (shrink)